The short version:
Over 40% of adults are deficient in Vitamin D — but most people taking it are making at least one of three common mistakes. Taking it at the wrong time, without fat, or without K2 to direct it properly. Here's what actually matters for getting it right.
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Vitamin D was one of the top five sellers in my store. Consistently. Every month, without fail.
And yet — I can’t tell you how many customers came back frustrated, saying their doctor just told them their Vitamin D levels were still low after months of supplementing. They weren’t skipping doses. They weren’t buying bad products. They were doing something that seems completely logical but quietly kills absorption: taking it wrong.
This happened so often that I started asking every Vitamin D customer the same two questions: what time of day are you taking it, and what are you eating when you take it?
The answers explained everything.
After many years of these conversations, here’s the full protocol I recommended more than any other:
I got this question constantly toward the end of my store’s run, as K2 started getting more attention in the supplement world. Here’s my honest take on it.
The logic is sound: Vitamin D increases calcium absorption from your gut. More calcium in circulation is great for bones — but calcium also has a tendency to deposit in soft tissues and arteries if it isn’t properly directed. Vitamin K2, specifically the MK-7 form, activates proteins that shuttle calcium into bones and teeth and away from arterial walls.
The research isn’t as definitive as the Vitamin D research — this is a newer area and we need more long-term human trials. But the mechanism makes biological sense, the risk of adding K2 to your routine is essentially zero at normal doses, and some of the cardiovascular research on K2 is genuinely compelling.
My personal take: if you’re taking Vitamin D3 at 2,000 IU or above on a regular basis, adding K2 (100 to 200 mcg of MK-7 daily) is a reasonable and low-risk decision. If you’re just taking a standard 1,000 IU dose in a multivitamin, don’t stress about it.
This is something I didn’t see discussed enough in the store, so I want to address it directly.
The groups most likely to be genuinely deficient, not just borderline low, include:
If you fall into any of these categories, supplementation isn’t optional — it’s genuinely important.
People occasionally ask whether you can take too much Vitamin D. The answer is yes — but the threshold is much higher than most people realize and is essentially impossible to hit through normal supplementation.
Vitamin D toxicity, which causes hypercalcemia (too much calcium in the blood), has been documented at sustained doses of 10,000 IU or more per day over extended periods. At 2,000 to 4,000 IU daily — the range I recommend — you are nowhere near that territory.
The nuance is that individual response varies. Some people are “hyperresponders” who raise their levels quickly on relatively low doses. This is another reason to get tested — it removes the guesswork and tells you exactly where you stand.
Vitamin D is one of the supplements I feel most confident recommending because the deficiency is genuinely widespread, the consequences of being chronically low are real — suppressed immunity, low mood, bone health decline, hormonal disruption — and the fix is inexpensive and straightforward.
But only if you take it right.
With fat. In D3 form. At a meaningful dose. Every day.
Get tested, find your baseline, supplement appropriately, and retest in three months. That’s it. No complicated protocol, no expensive products — just fixing the basics that most people are getting wrong.
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Get Free PDF1. Holick, M.F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266–281.
2. Tripkovic, L., et al. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. American Journal of Clinical Nutrition, 95(6), 1357–1364.
3. Heaney, R.P., et al. (2011). Vitamin D3 is more potent than vitamin D2 in humans. Journal of Clinical Endocrinology & Metabolism, 96(3), E447–E452.
4. Scragg, R., et al. (2018). Effect of monthly high-dose vitamin D supplementation on cardiovascular disease. JAMA Cardiology, 2(6), 608–616.
5. Gröber, U., et al. (2013). Vitamin D: Update 2013 — from rickets prophylaxis to general preventive healthcare. Dermato-Endocrinology, 5(3), 331–347.
6. Theuwissen, E., et al. (2012). The role of vitamin K in soft-tissue calcification. Advances in Nutrition, 3(2), 166–173. (K2 reference)
All references are peer-reviewed studies or position stands from reputable organizations.